2-naphthylamine toxicity
نویسندگان
چکیده
منابع مشابه
Carcinogenicity testing of N-hydroxy and other oxidation and decomposition products of 1- and 2-naphthylamine.
Af-Hydroxy-2-naphthylamine produced bladder tumors in three of four dogs when administered over a period of 30 months (dogs were sacrificed 15 months later) in dimethyl sulfoxide solution by repeated instillation directly into the bladders. ./V-Hydroxy-1-naphthylamine was more carcinogenic than TV-hydroxy^-naphthylamine by administration to rats, but the reverse was observed in four experiments...
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Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms. Likewise l-naphthylamine and 2-naphthylamine are also nonmutagenic but the N-hydroxy derivatives are mutagenic in microorganisms. Apparently these compounds require metabolism to breakdown products which are then the proximately active agents, and microorganisms lack the ...
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A series of 4-Thiazolidinone derivatives were synthesized by reaction of 3-formyl-2-arylindole derivatives, 2aminonaphthaline and mercaptoacetic acid. The structures of the new compounds were assigned on the basis of their analytical and spectral data.
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A new fluorometric assay for determining dipeptidyl peptidase IV (DPP IV; EC 3.4.14.5) was developed. The synthetic substrate glycyl-L-proline-4-methoxy-2-naphthylamide (20 mmol/L), Tris buffer (50 mmol/L, pH 8.3), and serum (20 microL) are mixed and incubated. The reaction is stopped with citrate (100 mmol/L, pH 4.0) and the released 4-methoxy-2-naphthylamine is measured fluorometrically. The ...
متن کاملCytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC(50) < 10 μg/mL) again...
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ژورنال
عنوان ژورنال: Medycyna Pracy
سال: 2020
ISSN: 0465-5893,2353-1339
DOI: 10.13075/mp.5893.00921